3-Fluorophenylacetic acid → 2-[(3-Fluorophenyl)acetamido]butyric acid isobutyl ester

HRID 133371

Reaktionsgleichung

Reaktionsgleichung von HRID 133371
[F:1][C:2]1[CH:3]=[C:4]([CH2:8][C:9]([OH:11])=O)[CH:5]=[CH:6][CH:7]=1.[NH2:12][CH:13]([CH2:21][CH3:22])[C:14]([O:16][CH2:17][CH:18]([CH3:20])[CH3:19])=[O:15]>>[CH2:17]([O:16][C:14](=[O:15])[CH:13]([NH:12][C:9](=[O:11])[CH2:8][C:4]1[CH:5]=[CH:6][CH:7]=[C:2]([F:1])[CH:3]=1)[CH2:21][CH3:22])[CH:18]([CH3:19])[CH3:20]

Komponenten

3

Edukt 2

HCID 676173-Fluorophenylacetic acidHCID 13743360Isobutyl 2-aminobutyrate

Produkt 1

HCID 540199252-[(3-Fluorophenyl)acetamido]butyric acid isobutyl ester

Versuchsvorschrift

Following General Procedure BI above and using 3-fluorophenylacetic acid (Aldrich) and iso-butyl 2-aminobutyrate (prepared following General Procedure BJ above), the title compound was prepared. The reaction was monitored by tlc on silica gel and purification was by filtration as described in the general procedure.

Aufarbeitung

  1. customThe reaction was monitored by tlc on silica gel and purification
  2. filtrationwas by filtration

Quellen und Nachweise

ORD-Eintrag
ord-0af6e8c61b5f4860af562b7dd469ccfb
Quelldatensatz
uspto-grants-2008_06
Patentnummer
US07390801B2

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