3-Bromopyridine → 3-(4-Phenyl-1-piperidinyl)pyridine
Reaktionsgleichung
Brc1cccnc1.c1ccc(C2CCNCC2)cc1>CC#[N]->[Cu+](<-[N]#CC)(<-[N]#CC)<-[N]#CC.CN(C)c1ccc(P(C2CCCCC2)C2CCCCC2)cc1.CS(C)=O.C[Si](C)(C)[O-].O=S(=O)([O-])C(F)(F)F.[Na+]>c1ccc(C2CCN(c3cccnc3)CC2)cc1Komponenten
9
Edukt 2
Produkt 3
Reagenzien, Katalysatoren, Lösungsmittel 4
Reaktionsbedingungen
- Temperatur
- 60 °C
Aufarbeitung
- customThe foil sealing tape was removed from the plate.
- addition3 μL of a 0.0667 M solution of caffeine in DMSO was added to each reaction well using an SPT Labtech Mosquito® liquid handling robot
- filtrationThe plates were then centrifuged for 15 to 20 seconds. · liquid-Phase beibehalten
- aliquotFollowing centrifugation, 500 nL of the resultant mixture from each well was carefully dispensed into four 384-well analytical plates (Analytical Sales # 38435) using an SPT Labtech Mosquito® liquid handling robot. Each well of these analytical plates contained 30 μL of DMSO with 0.1% acetic acid, pre-dosed by OpenTrons, to facilitate analysis.
Quellen und Nachweise
- ORD-Eintrag
- ord-a159e428b9584d93b0f1515ed4b0c342
- Quelldatensatz
- High-throughput exploration of 50,688 Pd-, Ni- and Cu-catalysed C–N coupling reactions
- Originallink
- Quelle ansehen
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