Reaktionsgleichung
C(OC(C1C=CC=CC=1O[C:9]1[C:23]([O:24][C:25]2[CH:30]=[CH:29][C:28]([S:31]([CH3:34])(=[O:33])=[O:32])=[CH:27][CH:26]=2)=[CH:22][C:12]2[NH:13][C:14]([C:16]3[CH:21]=[CH:20][CH:19]=[CH:18][N:17]=3)=[N:15][C:11]=2[CH:10]=1)=O)C.[NH:39]1[CH2:43][CH2:42][CH2:41][CH:40]1[CH:44]([OH:46])[CH3:45]>>[CH3:34][S:31]([C:28]1[CH:27]=[CH:26][C:25]([O:24][C:23]2[C:9]([N:39]3[CH2:43][CH2:42][CH2:41][CH:40]3[CH:44]([OH:46])[CH3:45])=[CH:10][C:11]3[NH:15][C:14]([C:16]4[CH:21]=[CH:20][CH:19]=[CH:18][N:17]=4)=[N:13][C:12]=3[CH:22]=2)=[CH:30][CH:29]=1)(=[O:33])=[O:32]Komponenten
3
Versuchsvorschrift
The entitled compound was obtained as a pale yellow solid, diastereomer mixture, in the same method as in Example 15 or in accordance with the method or by combining it with an ordinary method but using 5-fluoro-4-(4-methanesulfonyl-phenoxy)-2-nitro-phenylamine obtained in Example 14 and 1-pyrrolidin-2-yl-ethanol. The resulting diastereomer mixture was purified through partitioning thin-layer chromatography (Kieselgel™ 60F254, Art 5744 (by Merck), chloroform/methanol=10/1) into the individual diastereomers A and B each as a pale yellow solid.
Aufarbeitung
- customThe entitled compound was obtained as a pale yellow solid, diastereomer mixture, in the same method as in Example 15 or in accordance with the method
- customThe resulting diastereomer mixture was purified
- customthrough partitioning thin-layer chromatography (Kieselgel™ 60F254, Art 5744 (by Merck), chloroform/methanol=10/1) into the individual diastereomers A and B each as a pale yellow solid
Quellen und Nachweise
- ORD-Eintrag
- ord-9abad2e1b6d44c2797b1e68d68c16b95
- Quelldatensatz
- uspto-grants-2010_06
- Patentnummer
- US07728025B2
Verknüpfte Notizen
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