Reaktionsgleichung
[F:1][C:2]1[CH:7]=[C:6]([OH:8])[CH:5]=[CH:4][C:3]=1[NH:9][C:10](=[O:12])[CH3:11].[C:13]([C:15]1[CH:20]=[CH:19][C:18]([NH:21][C:22]([C:24]2([CH3:27])[CH2:26][O:25]2)=[O:23])=[CH:17][C:16]=1[CH3:28])#[N:14]>>[C:10]([NH:9][C:3]1[CH:4]=[CH:5][C:6]([O:8][CH2:27][C:24]([OH:25])([CH3:26])[C:22]([NH:21][C:18]2[CH:19]=[CH:20][C:15]([C:13]#[N:14])=[C:16]([CH3:28])[CH:17]=2)=[O:23])=[CH:7][C:2]=1[F:1])(=[O:12])[CH3:11]Komponenten
3
Versuchsvorschrift
3-(4-Acetylamino-3-fluorophenoxy)-N-(4-cyano-3-methylphenyl)-2-hydroxy-2-methylpropionamide was prepared as described in Example 1 starting from N-(2-fluoro-4-hydroxyphenyl)acetamide and 2-methyl-oxirane-2-carboxylic acid (4-cyano-3-methylphenyl)amide. 1H NMR (DMSO-d6): 1.41 (3H, s), 2.02 (3H, s), 2.44 (3H, s), 3.95 (1H, d, J=9.8 Hz), 4.26 (1H, d, J=9.8 Hz), 6.21 (1H, bs), 6.72 (1H, m), 6.86 (1H, m),7.56 (1H, m,) 7.69 (1H, d, J=9.0 Hz), 7.78 (1H, dd, J=9.0 Hz and 2.2 Hz), 7.93 (1H, d, J=2.2 Hz), 9.51 (1H, s), 9.99 (1H, bs).
Quellen und Nachweise
- ORD-Eintrag
- ord-e16f61a13d404482b6839223858d160a
- Quelldatensatz
- uspto-grants-2008_06
- Patentnummer
- US07390923B2
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