4-(2-Methoxyethyl)phenol → HCID 67526509, Verbindung

HRID 133754

Reaktionsgleichung

Reaktionsgleichung von HRID 133754
[CH3:1][O:2][CH2:3][CH2:4][C:5]1[CH:10]=[CH:9][C:8]([OH:11])=[CH:7][CH:6]=1.[CH3:12][C:13]1[C:18]([N+:19]([O-:21])=[O:20])=[CH:17][CH:16]=[CH:15][C:14]=1[NH:22][C:23]([C:25]1([CH3:28])[CH2:27][O:26]1)=[O:24]>>[OH:26][C:25]([CH3:28])([CH2:27][O:11][C:8]1[CH:9]=[CH:10][C:5]([CH2:4][CH2:3][O:2][CH3:1])=[CH:6][CH:7]=1)[C:23]([NH:22][C:14]1[CH:15]=[CH:16][CH:17]=[C:18]([N+:19]([O-:21])=[O:20])[C:13]=1[CH3:12])=[O:24]

Komponenten

3

Edukt 2

HCID 925164-(2-Methoxyethyl)phenolHCID 714200022-Methyl-N-(2-methyl-3-nitrophenyl)oxirane-2-carboxamide

Produkt 1

HCID 67526509HCID 67526509, Verbindung

Versuchsvorschrift

2-Hydroxy-3-[4-(2-methoxyethyl)phenoxy]-2-methyl-N-(2-methyl-3-nitrophenyl)propionamide was prepared as described in Example 1 starting from 4-methoxyethylphenol and 2-methyloxirane-2-carboxylic acid (2-methyl-3-nitrophenyl)amide. The crude product was purified by flash chromatography (dichloromethane-2% methanol). 1H NMR (400 MHz, DMSO-d6): 1.44 (3H, s), 2.28 (3H, s), 2.72 (2H, t, J=6.8 Hz), 3.22 (3H, s), 3.47 (2H, t, J=6.8 Hz), 3.94 (1H, d, J=9.4 Hz), 4.15 (1H, d, J=9.4 Hz), 6.11 (1H, s), 6.84 (2H, d, J=7.9 Hz), 7.12 (2H, d, J=7.9 Hz), 7.41-7.45 (1H, m), 7.65-7.68 (1H, m), 7.72-7.75 (1H, m), 9.71 (1H, s).

Aufarbeitung

  1. customThe crude product was purified by flash chromatography (dichloromethane-2% methanol)

Quellen und Nachweise

ORD-Eintrag
ord-7475e17ff6df463a84ddded44da58bf2
Quelldatensatz
uspto-grants-2008_06
Patentnummer
US07390923B2

Verknüpfte Notizen

Wird geladen…