2,3-Difluorobenzonitrile → 4-(2-cyano-6-fluoro-phenoxy)-6-(6-ethanesulfonyl-pyridin-3-yloxy)-2-pyridin-2-yl-1H-benzimidazole

HRID 13379

Reaktionsgleichung

Reaktionsgleichung von HRID 13379
[OH:1][C:2]1[C:10]2[N:9]=[C:8]([C:11]3[CH:16]=[CH:15][CH:14]=[CH:13][N:12]=3)[NH:7][C:6]=2[CH:5]=[C:4]([O:17][C:18]2[CH:19]=[N:20][C:21]([S:24]([CH2:27][CH3:28])(=[O:26])=[O:25])=[CH:22][CH:23]=2)[CH:3]=1.F[C:30]1[C:37]([F:38])=[CH:36][CH:35]=[CH:34][C:31]=1[C:32]#[N:33]>>[C:32]([C:31]1[CH:34]=[CH:35][CH:36]=[C:37]([F:38])[C:30]=1[O:1][C:2]1[C:10]2[N:9]=[C:8]([C:11]3[CH:16]=[CH:15][CH:14]=[CH:13][N:12]=3)[NH:7][C:6]=2[CH:5]=[C:4]([O:17][C:18]2[CH:19]=[N:20][C:21]([S:24]([CH2:27][CH3:28])(=[O:25])=[O:26])=[CH:22][CH:23]=2)[CH:3]=1)#[N:33]

Komponenten

3

Edukt 2

HCID 889352,3-DifluorobenzonitrileHCID 1356979674-hydroxy-6-(6-ethanesulfonyl-pyridin-3-yloxy)-2-pyridin-2-yl-1H-benzimidazole

Produkt 1

HCID 231453574-(2-cyano-6-fluoro-phenoxy)-6-(6-ethanesulfonyl-pyridin-3-yloxy)-2-pyridin-2-yl-1H-benzimidazole

Versuchsvorschrift

The entitled compound was obtained in the same method as in Example 251 (step 2) or in accordance with the method or by combining it with an ordinary method but using 4-hydroxy-6-(6-ethanesulfonyl-pyridin-3-yloxy)-2-pyridin-2-yl-1H-benzimidazole and 2,3-difluorobenzonitrile.

Aufarbeitung

  1. customThe entitled compound was obtained in the same method as in Example 251 (step 2) or in accordance with the method

Quellen und Nachweise

ORD-Eintrag
ord-2d5045f790684d51b8cb06ed1862fd64
Quelldatensatz
uspto-grants-2010_06
Patentnummer
US07728025B2

Verknüpfte Notizen

Wird geladen…