N-(tert-butoxycarbonyl)glycine → N-(2-(2-(6-(4-Methanesulfonyl-phenoxy)-2-pyridin-2-yl-3H-benzimidazol-5-yl)-pyrrolidin-1-yl)-2-oxo-ethyl)-methanesulfonamide

HRID 13390Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 13390
[CH3:1][S:2]([C:5]1[CH:31]=[CH:30][C:8]([O:9][C:10]2[C:24]([CH:25]3[CH2:29][CH2:28][CH2:27][NH:26]3)=[CH:23][C:13]3[NH:14][C:15]([C:17]4[CH:22]=[CH:21][CH:20]=[CH:19][N:18]=4)=[N:16][C:12]=3[CH:11]=2)=[CH:7][CH:6]=1)(=[O:4])=[O:3].C(OC([NH:39][CH2:40][C:41]([OH:43])=O)=O)(C)(C)C>>[CH3:1][S:2]([C:5]1[CH:6]=[CH:7][C:8]([O:9][C:10]2[C:24]([CH:25]3[CH2:29][CH2:28][CH2:27][N:26]3[C:41](=[O:43])[CH2:40][NH:39][S:2]([CH3:1])(=[O:4])=[O:3])=[CH:23][C:13]3[NH:14][C:15]([C:17]4[CH:22]=[CH:21][CH:20]=[CH:19][N:18]=4)=[N:16][C:12]=3[CH:11]=2)=[CH:30][CH:31]=1)(=[O:3])=[O:4]

Komponenten

3

Edukt 2

HCID 78288N-(tert-butoxycarbonyl)glycineHCID 231451755-(4-methanesulfonyl-phenoxy)-2-pyridin-2-yl-6-pyrrolidin-2-yl-1H-benzimidazole

Produkt 1

HCID 23145250N-(2-(2-(6-(4-Methanesulfonyl-phenoxy)-2-pyridin-2-yl-3H-benzimidazol-5-yl)-pyrrolidin-1-yl)-2-oxo-ethyl)-methanesulfonamide

Versuchsvorschrift

The entitled compound was obtained in the same method as in Example 171 and 178 or in accordance with the method or by combining it with an ordinary method but using 5-(4-methanesulfonyl-phenoxy)-2-pyridin-2-yl-6-pyrrolidin-2-yl-1H-benzimidazole obtained in Example 162 (step 7) and N-t-butoxycarbonyl-glycine.

Aufarbeitung

  1. customThe entitled compound was obtained in the same method as in Example 171 and 178 or in accordance with the method

Quellen und Nachweise

ORD-Eintrag
ord-a4bd50c417f84796980d10fce0e3b876
Quelldatensatz
uspto-grants-2010_06
Patentnummer
US07728025B2

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