N-(tert-butoxycarbonyl)glycine → Ethyl (2-(2-(6-(4-methanesulfonyl-phenoxy)-2-pyridin-2-yl-3H-benzimidazol-5-yl)-pyrrolidin-1-yl)-2-oxo-ethyl)-carbamate

HRID 13391Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 13391
[CH3:1][S:2]([C:5]1[CH:31]=[CH:30][C:8]([O:9][C:10]2[C:24]([CH:25]3[CH2:29][CH2:28][CH2:27][NH:26]3)=[CH:23][C:13]3[NH:14][C:15]([C:17]4[CH:22]=[CH:21][CH:20]=[CH:19][N:18]=4)=[N:16][C:12]=3[CH:11]=2)=[CH:7][CH:6]=1)(=[O:4])=[O:3].[C:32]([O:36][C:37]([NH:39][CH2:40][C:41](O)=[O:42])=[O:38])(C)(C)[CH3:33]>>[CH3:1][S:2]([C:5]1[CH:6]=[CH:7][C:8]([O:9][C:10]2[C:24]([CH:25]3[CH2:29][CH2:28][CH2:27][N:26]3[C:41](=[O:42])[CH2:40][NH:39][C:37](=[O:38])[O:36][CH2:32][CH3:33])=[CH:23][C:13]3[NH:14][C:15]([C:17]4[CH:22]=[CH:21][CH:20]=[CH:19][N:18]=4)=[N:16][C:12]=3[CH:11]=2)=[CH:30][CH:31]=1)(=[O:3])=[O:4]

Komponenten

3

Edukt 2

HCID 78288N-(tert-butoxycarbonyl)glycineHCID 231451755-(4-methanesulfonyl-phenoxy)-2-pyridin-2-yl-6-pyrrolidin-2-yl-1H-benzimidazole

Produkt 1

HCID 86619214Ethyl (2-(2-(6-(4-methanesulfonyl-phenoxy)-2-pyridin-2-yl-3H-benzimidazol-5-yl)-pyrrolidin-1-yl)-2-oxo-ethyl)-carbamate

Versuchsvorschrift

The entitled compound was obtained in the same method as in Example 171 and 181 or in accordance with the method or by combining it with an ordinary method but using 5-(4-methanesulfonyl-phenoxy)-2-pyridin-2-yl-6-pyrrolidin-2-yl-1H-benzimidazole obtained in Example 162 (step 7) and N-t-butoxycarbonyl-glycine.

Aufarbeitung

  1. customThe entitled compound was obtained in the same method as in Example 171 and 181 or in accordance with the method

Quellen und Nachweise

ORD-Eintrag
ord-14c0c2104d9d4b868d1102d3db6bba65
Quelldatensatz
uspto-grants-2010_06
Patentnummer
US07728025B2

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