Methanamine, N-methoxy-, hydrochloride (1:1) → 2-fluoro-N-methoxy-N-methylbenzamide

HRID 13418

Reaktionsgleichung

Reaktionsgleichung von HRID 13418
Cl.[CH3:2][O:3][NH:4][CH3:5].Cl.C(N=C=NCCCN(C)C)C.[F:18][C:19]1[CH:27]=[C:26]([N+]([O-])=O)[CH:25]=[CH:24][C:20]=1[C:21]([OH:23])=O>N1C=CC=CC=1>[F:18][C:19]1[CH:27]=[CH:26][CH:25]=[CH:24][C:20]=1[C:21]([N:4]([O:3][CH3:2])[CH3:5])=[O:23]

Komponenten

5

Edukt 3

HCID 81138Methanamine, N-methoxy-, hydrochloride (1:1)HCID 3026792-Fluoro-4-nitrobenzoic acidHCID 27239391,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochloride

Produkt 1

HCID 183575562-fluoro-N-methoxy-N-methylbenzamide

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 1049PyridineLösungsmittel

Versuchsvorschrift

5.79 g of N-methoxy-N-methylamine hydrochloride and 12.4 g of 1-ethyl-3-(3′-dimethylaminopropyl)-carbodiimide hydrochloride were added to a pyridine (80 ml) suspension of 10 g of 2-fluoro-4-nitrobenzoic acid, and the reaction liquid was stirred overnight at room temperature. Pyridine was evaporated away under reduced pressure, and water was added to it. The resulting deposit was taken out through filtration, washed with water, and dried to obtain the entitled compound as a pale yellow solid.

Aufarbeitung

  1. customthe reaction liquid
  2. customPyridine was evaporated away under reduced pressure, and water
  3. additionwas added to it
  4. filtrationThe resulting deposit was taken out through filtration
  5. washwashed with water
  6. customdried

Quellen und Nachweise

ORD-Eintrag
ord-76d5f9db0bc242af8f1bbe578660f790
Quelldatensatz
uspto-grants-2010_06
Patentnummer
US07728025B2

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