HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
4-Amino-3-Nitrophenol → 2-Nitro-4-(4-(3-pyridyl)pyrimidin-2-yloxy)phenylamine
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | 4-Amino-3-Nitrophenol | HCID 3758882 | — |
| Edukt | 2-Chloro-4-(pyridin-3-yl)pyrimidine | HCID 11805543 | — |
| Lösungsmittel | Dimethylformamide | HCID 6228 | — |
| Produkt | 2-Nitro-4-(4-(3-pyridyl)pyrimidin-2-yloxy)phenylamine | HCID 22041340 | — |
Reaktionsschritte
A solution of 4-amino-3-nitro-phenol (1 eq) and 2-chloro-4-(3-pyridyl)pyrimidine (1 eq) in N,N-dimethylformamide was microwaved at 150° C. for 10 mins. The reaction mixture was partitioned between ethyl acetate and water. The organic layer was concentrated and purified on silica gel to yield 2-nitro-4-(4-(3-pyridyl)pyrimidin-2-yloxy)phenylamine. MS: MH+=309.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US07728010B2 |
| Quelldatensatz | uspto-grants-2010_06 |
| ORD ID | ord-58cd6e076cab44f498affe8c636383fd |
| Quellennotiz | uspto-grants-2010_06 |