Ethanol → HCID 69141826, Verbindung

HRID 1348949Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1348949
[CH2:1]1[C:10]2[C:5](=[CH:6][CH:7]=[C:8]([CH:11]([C:16]3[CH:21]=[CH:20][N:19]=[CH:18][CH:17]=3)[CH2:12][C:13]([OH:15])=[O:14])[CH:9]=2)[CH2:4][CH2:3][NH:2]1.C(=O)(O)[O-].[Na+].[CH2:27](O)[CH3:28]>Cl>[CH2:27]([O:14][C:13](=[O:15])[CH2:12][CH:11]([C:8]1[CH:9]=[C:10]2[C:5]([CH2:4][CH2:3][NH:2][CH2:1]2)=[CH:6][CH:7]=1)[C:16]1[CH:21]=[CH:20][N:19]=[CH:18][CH:17]=1)[CH3:28]

Komponenten

5

Edukt 3

HCID 702EthanolHCID 516892Sodium BicarbonateHCID 210924353-(1,2,3,4-Tetrahydro-isoquinolin-7-yl)-3-(pyrid-4-yl)-propionic acid

Produkt 1

HCID 69141826HCID 69141826, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 313Hydrochloric AcidKatalysator

Versuchsvorschrift

A solution of 3-(1,2,3,4-tetrahydro-isoquinolin-7-yl)-3-(pyrid-4-yl)-propionic acid, enantiomer A {Reference Example 18(a)} in ethanol (50 mL) was treated with concentrated hydrochloric acid (two drops) and then heated at reflux temperature, under nitrogen, for 8 hours. The pH of the reaction mixture was adjusted to ˜5 by dropwise addition of sodium bicarbonate solution (5%) and this mixture was then evaporated to give the title compound which was used without further purification.

Aufarbeitung

  1. temperatureheated
  2. temperatureat reflux temperature
  3. customthis mixture was then evaporated

Quellen und Nachweise

ORD-Eintrag
ord-824b961eb6544d678e784cde14d7b3a3
Quelldatensatz
uspto-grants-2007_05
Patentnummer
US07211586B2

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