Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|
| Edukt | Methyl iodide | HCID 6328 | — |
| Edukt | 4-Isothiocyanatobenzoic acid | HCID 242946 | — |
| Edukt | 4-(3-Amino-4-methylamino-phenoxy)-pyridine-2-carboxylic acid methylamide | HCID 17755838 | — |
| Lösungsmittel | Methanol | HCID 887 | — |
| Produkt | Benzoic Acid | HCID 243 | — |
Reaktionsschritte
To {4-[3-amino-4-(methylamino)phenoxy](2-pyridyl)}-N-methylcarboxamide (1 eq) in methanol was added 4-isothiocyanatobenzoic acid (1 eq) and stirred at 60° C. for 3 h. To it was then added iodomethane (1 eq) and heated to 60° C. for 3 h. and concentrated the solvent and purified on silica gel to yield 4-({1-methyl-5-[2-(N-methylcarbamoyl)(4-pyridyloxy))]benzimidazol-2-yl}amino)benzoic acid. MS: MH+=417.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patentnummer | US07728010B2 |
|---|
| Quelldatensatz | uspto-grants-2010_06 |
|---|
| ORD ID | ord-0db3fcedba7b4eb1b027317ca6693d87 |
|---|
| Quellennotiz | uspto-grants-2010_06 |
|---|
