Reaktionsgleichung
[CH2:1]([O:4][N:5]=[C:6]1[CH2:10][N:9]([C:11]([O:13]C(C)(C)C)=O)[C@H:8]([C:18]([OH:20])=O)[CH2:7]1)[CH:2]=[CH2:3].[C:21]([C:23]1[CH:31]=[CH:30][C:26](C(Cl)=O)=[CH:25][CH:24]=1)#[N:22].[N:32]1([C:37]2[CH:42]=[CH:41][CH:40]=[CH:39][C:38]=2[NH2:43])[CH:36]=[CH:35][CH:34]=[CH:33]1>>[CH2:1]([O:4][N:5]=[C:6]1[CH2:10][N:9]([C:11](=[O:13])[C:26]2[CH:25]=[CH:24][C:23]([C:21]#[N:22])=[CH:31][CH:30]=2)[C@H:8]([C:18]([NH:43][C:38]2[CH:39]=[CH:40][CH:41]=[CH:42][C:37]=2[N:32]2[CH:36]=[CH:35][CH:34]=[CH:33]2)=[O:20])[CH2:7]1)[CH:2]=[CH2:3]Komponenten
4
Versuchsvorschrift
Following the general method as outlined in Example 22, starting from (2S,4EZ)-4-[(allyloxy)-imino]-1-(tert-butoxycarbonyl)-2-pyrrolidinecarboxylic acid, 4-cyanobenzoyl chloride, and 2-(1H-pyrrol-1-yl)phenylamine the title compound was obtained in 51% purity by LC/MS. MS(ESI+): m/z=454.4.
Quellen und Nachweise
- ORD-Eintrag
- ord-b609a776f69b4e1985ac5b7f3c265320
- Quelldatensatz
- uspto-grants-2007_05
- Patentnummer
- US07211601B2
Verknüpfte Notizen
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