2-(1H-pyrrol-1-yl)aniline → (2S,4EZ)-4-(methoxyimino)-N1-pentyl-N2-[2-(1H-pyrrol-1-yl)phenyl]-1,2-pyrrolidinedicarboxamide

HRID 1349038

Reaktionsgleichung

Reaktionsgleichung von HRID 1349038
C(O[C:6]([N:8]1[CH2:12][C:11](=[N:13][O:14][CH3:15])[CH2:10][C@H:9]1[C:16]([OH:18])=O)=[O:7])(C)(C)C.[N:19]([CH2:22][CH2:23][CH2:24][CH2:25][CH3:26])=C=O.[N:27]1([C:32]2[CH:37]=[CH:36][CH:35]=[CH:34][C:33]=2[NH2:38])[CH:31]=[CH:30][CH:29]=[CH:28]1>>[CH3:15][O:14][N:13]=[C:11]1[CH2:12][N:8]([C:6]([NH:19][CH2:22][CH2:23][CH2:24][CH2:25][CH3:26])=[O:7])[C@H:9]([C:16]([NH:38][C:33]2[CH:34]=[CH:35][CH:36]=[CH:37][C:32]=2[N:27]2[CH:28]=[CH:29][CH:30]=[CH:31]2)=[O:18])[CH2:10]1

Komponenten

4

Edukt 3

HCID 801232-(1H-pyrrol-1-yl)anilineHCID 206036Pentane, 1-isocyanato-HCID 58714586(2S,4EZ)-1(tert-butoxycarbonyl)-4-(methoxyimino)-2-pyrrolidinecarboxylic acid

Produkt 1

HCID 131725423(2S,4EZ)-4-(methoxyimino)-N1-pentyl-N2-[2-(1H-pyrrol-1-yl)phenyl]-1,2-pyrrolidinedicarboxamide

Versuchsvorschrift

Following the general method as outlined in Example 22, starting from (2S,4EZ)-1-(tert-butoxycarbonyl)-4-(methoxyimino)-2-pyrrolidinecarboxylic acid, 1-isocyanatopentane, and 2-(1H-pyrrol-1-yl)phenylamine the title compound was obtained in 74% purity by LC/MS. MS(ESI+): m/z=412.2.

Quellen und Nachweise

ORD-Eintrag
ord-d61d6efcfc8e41ea93f975272bd100b0
Quelldatensatz
uspto-grants-2007_05
Patentnummer
US07211601B2

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