HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
2,1,3-Benzothiadiazol-4-amine → (2S,4EZ)-N-(2,1,3-benzothiadiazol-4-yl)-4-(cyanomethylene)-1-(diphenylacetyl)-2-pyrrolidinecarboxamide
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | 2,1,3-Benzothiadiazol-4-amine | HCID 69845 | — |
| Edukt | 2,2-Diphenylacetyl chloride | HCID 74637 | — |
| Edukt | (2S,4EZ)-1-(tertbutoxycarbonyl)-4-(cyanomethylene)-2-pyrrolidinecarboxylic acid | HCID 69250314 | — |
| Produkt | (2S,4EZ)-N-(2,1,3-benzothiadiazol-4-yl)-4-(cyanomethylene)-1-(diphenylacetyl)-2-pyrrolidinecarboxamide | HCID 69249372 | — |
Reaktionsschritte
Following the general method as outlined in Example 22, startling from (2S,4EZ)-1-(tert-butoxycarbonyl)-4-(cyanomethylene)-2-pyrrolidinecarboxylic acid, diphenylacetyl chloride, and 2,1,3-benzothiadiazol-4-amine the title compound was obtained in 42% purity by LC/MS. MS(ESI+): m/z=480.4.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US07211601B2 |
| Quelldatensatz | uspto-grants-2007_05 |
| ORD ID | ord-128cffabf3f049ba8b3e80d302fe5d50 |
| Quellennotiz | uspto-grants-2007_05 |