[Cl:1][C:2]1[CH:3]=[C:4]([CH:33]=[CH:34][CH:35]=1)[CH2:5][NH:6][C:7]([C:9]1[N:10]([CH2:27][CH:28]([O:31][CH3:32])[O:29][CH3:30])[CH:11]=[C:12]([C:24]([CH3:26])=[CH2:25])[C:13](=[O:23])[C:14]=1[O:15]CC1C=CC=CC=1)=[O:8].[H][H]>CO.[C].[Pd]>[Cl:1][C:2]1[CH:3]=[C:4]([CH:33]=[CH:34][CH:35]=1)[CH2:5][NH:6][C:7]([C:9]1[N:10]([CH2:27][CH:28]([O:31][CH3:32])[O:29][CH3:30])[CH:11]=[C:12]([CH:24]([CH3:25])[CH3:26])[C:13](=[O:23])[C:14]=1[OH:15])=[O:8]To a solution of 3-benzyloxy-1-(2,2-dimethoxyethyl)-5-isopropenyl-4-oxo-1,4-dihydropyridine-2-carboxylic acid 3-chlorobenzylamide (60 mg) in methanol (1 ml) was added 5% palladium-carbon (20 mg) and the mixture was stirred under an atmospheric pressure of hydrogen for 16 hr. A solid was filtered off and the filtrate was concentrated to give 1-(2,2-dimethoxyethyl)-3-hydroxy-5-isopropyl-4-oxo-1,4-dihydropyridine-2-carboxylic acid 3-chlorobenzylamide (43 mg).
Wird geladen…