Dimethylformamide → 1-Perhydro-2H-pyran-2-yl-3-[3-(3-piperidylpropanoylamino)phenyl]-1H-indazole-5-carboxamide

HRID 1349792

Reaktionsgleichung

Reaktionsgleichung von HRID 1349792
[NH:1]1[CH2:6][CH2:5][CH2:4][CH:3]([CH:7]([CH3:11])C(O)=O)[CH2:2]1.Cl.CN(C)CCCN=C=NCC.[NH2:24][C:25]1[CH:26]=[C:27]([C:31]2[C:39]3[C:34](=[CH:35][CH:36]=[C:37]([C:40]([NH2:42])=[O:41])[CH:38]=3)[N:33]([CH:43]3[CH2:48][CH2:47][CH2:46][CH2:45][O:44]3)[N:32]=2)[CH:28]=[CH:29][CH:30]=1.CN(C)[CH:51]=[O:52]>ClCCl>[O:44]1[CH2:45][CH2:46][CH2:47][CH2:48][CH:43]1[N:33]1[C:34]2[C:39](=[CH:38][C:37]([C:40]([NH2:42])=[O:41])=[CH:36][CH:35]=2)[C:31]([C:27]2[CH:28]=[CH:29][CH:30]=[C:25]([NH:24][C:51](=[O:52])[CH2:11][CH2:7][CH:3]3[CH2:4][CH2:5][CH2:6][NH:1][CH2:2]3)[CH:26]=2)=[N:32]1

Komponenten

6

Edukt 4

HCID 6228DimethylformamideHCID 27239391,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochlorideHCID 219803843-Piperidyl propanoic acidHCID 224799593-(3-Aminophenyl)-1-perhydro-2h-pyran-2-yl-1h-indazole5-carboxamide

Produkt 1

HCID 694257341-Perhydro-2H-pyran-2-yl-3-[3-(3-piperidylpropanoylamino)phenyl]-1H-indazole-5-carboxamide

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

To a solution of 3-piperidylpropanoic acid (0.102 g, 0.65 mmol) in 6 mL of dichloromethane was added 1-(3-dimethylaminopropyl)-3-ethyl carbodiimide hydrochloride (EDCI) (0.135 g, 0.71 mmol). After 10 min at room temperature, 3-(3-aminophenyl)-1-perhydro-2H-pyran-2-yl-1H-indazole-5-carboxamide (0.200 g, 0.59 mmol) was then added as a solid followed by 2 mL of dimethyl formamide. The reaction mixture was stirred at room temperature overnight. The crude mixture was partitioned between water and ethyl acetate. The crude was not purified (yield not calculated). ES-MS (m/z) 476 [M+H]+.

Aufarbeitung

  1. customThe crude mixture was partitioned between water and ethyl acetate
  2. customThe crude was not purified (
  3. customyield not

Quellen und Nachweise

ORD-Eintrag
ord-5a157284968e4e328a74e09128ac9571
Quelldatensatz
uspto-grants-2007_05
Patentnummer
US07211594B2

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