2-Bromobenzoyl chloride → (2-Bromophenyl)(4-methylpiperazin-1-yl)methanone

HRID 1350043Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1350043
[Br:1][C:2]1[CH:10]=[CH:9][CH:8]=[CH:7][C:3]=1[C:4](Cl)=[O:5].[CH3:11][N:12]1[CH2:17][CH2:16][NH:15][CH2:14][CH2:13]1>C1(C)C=CC=CC=1>[Br:1][C:2]1[CH:10]=[CH:9][CH:8]=[CH:7][C:3]=1[C:4]([N:15]1[CH2:16][CH2:17][N:12]([CH3:11])[CH2:13][CH2:14]1)=[O:5]

Komponenten

4

Edukt 2

HCID 235422-Bromobenzoyl chlorideHCID 531671-Methylpiperazine

Produkt 1

HCID 668767(2-Bromophenyl)(4-methylpiperazin-1-yl)methanoneAusbeute 78,5 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 1140TolueneLösungsmittel

Versuchsvorschrift

To a solution of 2-bromobenzoyl chloride (2 g, 9 mmol) in toluene (30 mL) was added N-methylpiperazine (2 mL, 18 mmol, 2 equiv.). The resulting mixture was stirred overnight. The precipitate was filtered and the filtrate was concentrated under reduced pressure. The residue was taken into dichloromethane, washed with water. The organic layer was concentrated under reduced pressure to give 2 g (77% yield) of intermediate 10.

Aufarbeitung

  1. filtrationThe precipitate was filtered
  2. concentrationthe filtrate was concentrated under reduced pressure
  3. washwashed with water
  4. concentrationThe organic layer was concentrated under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-a0aff40fd8cd48d497cc85e959dfde82
Quelldatensatz
uspto-grants-2007_05
Patentnummer
US07214676B2

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