Hydrochloric Acid → N-{4-[(1R)-1-aminoethyl]-2-methylphenyl)methanesulfonamide hydrochloride

HRID 1350845

Reaktionsgleichung

Reaktionsgleichung von HRID 1350845
C([S@]([NH:7][C@@H:8]([C:10]1[CH:15]=[CH:14][C:13]([NH:16][S:17]([CH3:20])(=[O:19])=[O:18])=[C:12]([CH3:21])[CH:11]=1)[CH3:9])=O)(C)(C)C.[ClH:22]>O1CCOCC1>[ClH:22].[NH2:7][C@@H:8]([C:10]1[CH:15]=[CH:14][C:13]([NH:16][S:17]([CH3:20])(=[O:19])=[O:18])=[C:12]([CH3:21])[CH:11]=1)[CH3:9]

Komponenten

4

Edukt 2

HCID 313Hydrochloric AcidHCID 58640404N-[4-((1R)-1-{[(R)-tert-butylsulfinyl]amino}ethyl)-2-methylphenyl]methanesulfonamide

Produkt 1

HCID 21097519N-{4-[(1R)-1-aminoethyl]-2-methylphenyl)methanesulfonamide hydrochloride

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 312751,4-DioxaneLösungsmittel

Versuchsvorschrift

To N-[4-((1R)-1-{[(R)-tert-butylsulfinyl]amino}ethyl)-2-methylphenyl]methanesulfonamide (530 mg,1.60 mmol) was added 10% methanolic hydrogen chloride (5.0 ml) and dioxane (5.0 ml). The solution was stirred at ambient temperature for 30 minutes and then concentrated under reduced pressure. Diethyl ether was added to precipitate amine hydrochloride. The precipitate was then filtered, washed with diethyl ether and collected to furnish 450 mg (quant.) of the title compound as a white solid.

Aufarbeitung

  1. concentrationconcentrated under reduced pressure
  2. additionDiethyl ether was added
  3. customto precipitate amine hydrochloride
  4. filtrationThe precipitate was then filtered
  5. washwashed with diethyl ether
  6. customcollected

Quellen und Nachweise

ORD-Eintrag
ord-8b544fffb3e84e5e96885c6b82505aac
Quelldatensatz
uspto-grants-2007_05
Patentnummer
US07214824B2

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