HCID 58640415, Verbindung → HCID 21097450, Verbindung

HRID 1350855Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1350855
[CH3:1][C:2]1([CH3:18])[C:10]2[C:5](=[CH:6][C:7]([O:11][CH2:12][C:13]([O:15]CC)=[O:14])=[CH:8][CH:9]=2)[CH2:4][CH2:3]1>C(O)C.[OH-].[Na+]>[CH3:1][C:2]1([CH3:18])[C:10]2[C:5](=[CH:6][C:7]([O:11][CH2:12][C:13]([OH:15])=[O:14])=[CH:8][CH:9]=2)[CH2:4][CH2:3]1

Komponenten

4

Edukt 1

HCID 58640415HCID 58640415, Verbindung

Produkt 1

HCID 21097450HCID 21097450, VerbindungAusbeute 89 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 702EthanolLösungsmittelHCID 14798Sodium HydroxideLösungsmittel

Versuchsvorschrift

A mixture of ethyl [(1,1-dimethyl-2,3-dihydro-1H-inden-5-yl)oxy]acetate (1.14 g, 4.58 mmol) in ethanol (20 ml) and 2M sodium hydroxide aqueous solution (4 ml) was refluxed for 2 hours. After cooling to ambient temperature, the solvent was evaporated in vacuo and the aqueous solution was acidified to pH 2 with 2M hydrochloride aqueous solution with ice-cooling. The precipitate solid was collected and dried in vacuo to give 894 mg (89% yield) of the title compound as a pale gray solid.

Aufarbeitung

  1. temperaturewas refluxed for 2 hours
  2. customthe solvent was evaporated in vacuo
  3. temperaturecooling
  4. customThe precipitate solid was collected
  5. customdried in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-6bc3efdb0cb64060858432a608c8d255
Quelldatensatz
uspto-grants-2007_05
Patentnummer
US07214824B2

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