Dimethylformamide → Dichlorobenzylidenamine

HRID 1350911

Reaktionsgleichung

Reaktionsgleichung von HRID 1350911
Cl.[Cl:2]CCC(N)(C)C.[Cl:9][C:10]1[CH:17]=[CH:16][CH:15]=[C:14](Cl)[C:11]=1C=O.C[N:20]([CH3:23])C=O>C1(C)C=CC=CC=1.C(C(OC(CC)(CC)C)(CC)C)C.O1CCCC1.CS(C)=O.C(Cl)Cl>[Cl:9][C:10]1[CH:17]=[CH:16][CH:15]=[CH:14][C:11]=1[C:23]([Cl:2])=[NH:20]

Komponenten

9

Edukt 3

HCID 6228DimethylformamideHCID 67372,6-DichlorobenzaldehydeHCID 210945474-Chloro-2-methylbutan-2-amine hydrochloride

Produkt 1

HCID 131726441Dichlorobenzylidenamine

Reagenzien, Katalysatoren, Lösungsmittel 5

HCID 679Dimethyl SulfoxideLösungsmittelHCID 1140TolueneLösungsmittelHCID 6344DichloromethaneLösungsmittelHCID 8028TetrahydrofuranLösungsmittelHCID 12430074DiethylethyletherLösungsmittel

Versuchsvorschrift

The base is liberated from about 80–90, preferably 84.0 mmol of 3-chloro-1,1-dimethylpropylamine-hydrochloride by known methods. The free base is dissolved in about 50 mL of a solvent, preferably toluene, diethylethylether, tetrahydrofuran, dimethylsulphoxide, dimethylformamide or methylene chloride and about 60 to 100 mmol, preferably 80.0 mmol of 2,6-dichlorobenzaldehyde are added at ambient temperature, with stirring. The reaction mixture is stirred for 5 to 20 h, preferably for 15 h at ambient temperature, dried again and the solvent is removed. The corresponding dichlorobenzylidenamine of compound (III) is obtained.

Aufarbeitung

  1. additionare added at ambient temperature
  2. stirringThe reaction mixture is stirred for 5 to 20 h, preferably for 15 h at ambient temperature
  3. customdried again
  4. customthe solvent is removed

Quellen und Nachweise

ORD-Eintrag
ord-6af98bf814c24801a9689cef8d7e3e26
Quelldatensatz
uspto-grants-2007_05
Patentnummer
US07214698B2

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