HCID 10155464, Verbindung → HCID 9858528, Verbindung

HRID 1351486Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1351486
Cl[C:2]1[N:7]=[N:6][C:5]([NH:8][CH2:9][CH:10]2[CH2:15][CH2:14][N:13]([C:16]([O:18][CH2:19][C:20]3[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=3)=[O:17])[CH2:12][CH2:11]2)=[CH:4][CH:3]=1.[H][H]>C(O)C.[Ni]>[N:7]1[CH:2]=[CH:3][CH:4]=[C:5]([NH:8][CH2:9][CH:10]2[CH2:15][CH2:14][N:13]([C:16]([O:18][CH2:19][C:20]3[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=3)=[O:17])[CH2:12][CH2:11]2)[N:6]=1

Komponenten

5

Edukt 2

HCID 10155464HCID 10155464, VerbindungHCID 178418361HCID 178418361, Verbindung

Produkt 1

HCID 9858528HCID 9858528, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 935NickelKatalysatorHCID 702EthanolLösungsmittel

Versuchsvorschrift

Benzyl 4-{[(6-chloro-3-pyridazinyl)amino]methyl}-1piperidinecarboxylate (EXAMPLE 22) (400 mg, 1.11 mmol) was dissolved in absolute ethanol. Raney nickel (65 mg, 1.11 mmol) was then added and the resulting reaction was stirred under 1 atm hydrogen for 18 h. The catalyst was filtered and the filtrate was concentrated under reduced pressure. The resulting clear oil was purified by silica gel chromatography to give the title compound as a clear oil.

Aufarbeitung

  1. customthe resulting reaction
  2. filtrationThe catalyst was filtered
  3. concentrationthe filtrate was concentrated under reduced pressure
  4. customThe resulting clear oil was purified by silica gel chromatography

Quellen und Nachweise

ORD-Eintrag
ord-7f4b5e06d6294421a5ff38c99bd1b0ac
Quelldatensatz
uspto-grants-2007_05
Patentnummer
US07217716B2

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