Trifluoroacetic acid → 4-[(3-Methoxy-pyrazin-2-ylamino)-methyl]-piperidine

HRID 1351580Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1351580
C(OC([N:8]1[CH2:13][CH2:12][CH:11]([CH2:14][NH:15][C:16]2[C:21]([O:22][CH3:23])=[N:20][CH:19]=[CH:18][N:17]=2)[CH2:10][CH2:9]1)=O)(C)(C)C.FC(F)(F)C(O)=O>>[CH3:23][O:22][C:21]1[C:16]([NH:15][CH2:14][CH:11]2[CH2:12][CH2:13][NH:8][CH2:9][CH2:10]2)=[N:17][CH:18]=[CH:19][N:20]=1

Komponenten

3

Edukt 2

HCID 6422Trifluoroacetic acidHCID 235773124-[(3-Methoxy-pyrazin-2-ylamino)-methyl]-piperidine-1-carboxylic acid tert-butyl ester

Produkt 1

HCID 221357494-[(3-Methoxy-pyrazin-2-ylamino)-methyl]-piperidine

Versuchsvorschrift

4-[(3-Methoxy-pyrazin-2-ylamino)-methyl]-piperidine-1-carboxylic acid tert-butyl ester (0.5 g, 0.0015 mol) and trifluoroacetic acid (5 mL) were allowed to stir under nitrogen for 0.5 h. The reaction was concentrated in vacuo, and chromatographed on silica using methylene chloride/methanol/ammonium hydroxide (90/10/2) to give the title compound. M.S. (M+1): 223.

Aufarbeitung

  1. concentrationThe reaction was concentrated in vacuo
  2. customchromatographed on silica

Quellen und Nachweise

ORD-Eintrag
ord-fe5342dcd0844061a8b4fc1d1bcc0bc6
Quelldatensatz
uspto-grants-2007_05
Patentnummer
US07217716B2

Notizen zur Reaktion

Wird geladen…