1-(5-Trifluoromethyl-[1,3,4]thiadiazol-2-yl)-piperazine trifluoroacetate → HCID 11605837, Verbindung
Reaktionsgleichung
[CH3:1][S:2]([C:5]1[CH:6]=[CH:7][C:8]([N:14]2[CH2:19][CH2:18][O:17][CH2:16][CH2:15]2)=[C:9]([CH:13]=1)[C:10]([OH:12])=O)(=[O:4])=[O:3].FC(F)(F)C(O)=O.[F:27][C:28]([F:41])([F:40])[C:29]1[S:33][C:32]([N:34]2[CH2:39][CH2:38][NH:37][CH2:36][CH2:35]2)=[N:31][N:30]=1>>[CH3:1][S:2]([C:5]1[CH:6]=[CH:7][C:8]([N:14]2[CH2:19][CH2:18][O:17][CH2:16][CH2:15]2)=[C:9]([C:10]([N:37]2[CH2:36][CH2:35][N:34]([C:32]3[S:33][C:29]([C:28]([F:40])([F:27])[F:41])=[N:30][N:31]=3)[CH2:39][CH2:38]2)=[O:12])[CH:13]=1)(=[O:3])=[O:4]Komponenten
3
Versuchsvorschrift
Prepared in analogy to example 1 (b) from 5-methanesulfonyl-2-morpholin-4-yl-benzoic acid (Example A13) and 1-(5-trifluoromethyl-[1,3,4]thiadiazol-2-yl)-piperazine trifluoroacetate (Example 62(b)). The crude material was purified by chromatography (SiO2, dichloromethane/methanol 99:1) to yield the title compound as a colorless solid. MS (m/e): 506.3 (M+H+, 100%).
Aufarbeitung
- customThe crude material was purified by chromatography (SiO2, dichloromethane/methanol 99:1)