1-(2-Piperazin-1-yl-thiazol-5-yl)-propan-1-one hydrochloride → 1-{2-[4-(2-Isopropoxy-5-methanesulfonyl-benzoyl)-piperazin-1-yl]-thiazol-5-yl}-propan-1-one
Reaktionsgleichung
[CH:1]([O:4][C:5]1[CH:13]=[CH:12][C:11]([S:14]([CH3:17])(=[O:16])=[O:15])=[CH:10][C:6]=1[C:7]([OH:9])=O)([CH3:3])[CH3:2].Cl.[N:19]1([C:25]2[S:26][C:27]([C:30](=[O:33])[CH2:31][CH3:32])=[CH:28][N:29]=2)[CH2:24][CH2:23][NH:22][CH2:21][CH2:20]1>>[CH:1]([O:4][C:5]1[CH:13]=[CH:12][C:11]([S:14]([CH3:17])(=[O:16])=[O:15])=[CH:10][C:6]=1[C:7]([N:22]1[CH2:23][CH2:24][N:19]([C:25]2[S:26][C:27]([C:30](=[O:33])[CH2:31][CH3:32])=[CH:28][N:29]=2)[CH2:20][CH2:21]1)=[O:9])([CH3:2])[CH3:3]Komponenten
3
Versuchsvorschrift
Prepared in analogy to example 1 (b) from 2-isopropoxy-5-methanesulfonyl-benzoic acid (Example A1) and 1-(2-piperazin-1-yl-thiazol-5-yl)-propan-1-one hydrochloride. The crude material was purified by chromatography (SiO2, methanol/dichloromethane) to yield the title compound as a light brown crystalline solid (yield 24%). MS (m/e): 466.0 (M+H+, 100%).