1-(5-Trifluoromethyl-thiazol-2-yl)-piperazine hydrochloride → HCID 21100318, Verbindung
Reaktionsgleichung
[CH3:1][S:2]([C:5]1[CH:6]=[CH:7][C:8]([S:14][CH3:15])=[C:9]([CH:13]=1)[C:10]([OH:12])=O)(=[O:4])=[O:3].Cl.[F:17][C:18]([F:31])([F:30])[C:19]1[S:23][C:22]([N:24]2[CH2:29][CH2:28][NH:27][CH2:26][CH2:25]2)=[N:21][CH:20]=1>>[CH3:1][S:2]([C:5]1[CH:6]=[CH:7][C:8]([S:14][CH3:15])=[C:9]([C:10]([N:27]2[CH2:28][CH2:29][N:24]([C:22]3[S:23][C:19]([C:18]([F:31])([F:17])[F:30])=[CH:20][N:21]=3)[CH2:25][CH2:26]2)=[O:12])[CH:13]=1)(=[O:3])=[O:4]Komponenten
3
Versuchsvorschrift
Prepared in analogy to example 1 (b) from 5-methanesulfonyl-2-methylsulfanyl-benzoic acid (Example A26) and 1-(5-trifluoromethyl-thiazol-2-yl)-piperazine hydrochloride (Example 58(c)). The crude material was purified by chromatography (SiO2, ethyl acetate/heptane) to yield the title compound as a light brown solid (yield 18%). MS (m/e): 466.0 (M+H+, 100%).
Aufarbeitung
- customThe crude material was purified by chromatography (SiO2, ethyl acetate/heptane)