Ethanol → 5,6-Dichloro-2-(4-carboxy-2-methoxyphenyl)benzimidazole

HRID 1352654Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1352654
[Cl:1][C:2]1[C:20]([Cl:21])=[CH:19][C:5]2[N:6]=[C:7]([C:9]3[CH:14]=[CH:13]C(C#N)=[CH:11][C:10]=3[O:17][CH3:18])[NH:8][C:4]=2[CH:3]=1.[OH-:22].[Na+].[CH2:24]([OH:26])[CH3:25]>>[Cl:1][C:2]1[C:20]([Cl:21])=[CH:19][C:5]2[N:6]=[C:7]([C:9]3[CH:14]=[CH:13][C:25]([C:24]([OH:22])=[O:26])=[CH:11][C:10]=3[O:17][CH3:18])[NH:8][C:4]=2[CH:3]=1

Komponenten

4

Edukt 3

HCID 702EthanolHCID 14798Sodium HydroxideHCID 211011705,6-Dichloro-2-(4-cyano-2-methoxyphenyl)benzimidazole

Produkt 1

HCID 211011665,6-Dichloro-2-(4-carboxy-2-methoxyphenyl)benzimidazoleAusbeute 46 %

Versuchsvorschrift

A solution of 5,6-dichloro-2-(4-cyano-2-methoxyphenyl)benzimidazole, prepared as described in Preparation 5, in ethanol (50 ml) and 2N NaOH (15 ml) was refluxed for 16 h. Solvent was removed under reduced pressure and the residue was acidified with 37% HCl (10 ml), stirred for 1 h. The solid was filtered, washed with water (50 ml), dried at 50° C. under vacuum to give 0.92 g of the title compound (yield 46%), mp>250° C.

Aufarbeitung

  1. customSolvent was removed under reduced pressure
  2. filtrationThe solid was filtered
  3. washwashed with water (50 ml)
  4. customdried at 50° C. under vacuum

Quellen und Nachweise

ORD-Eintrag
ord-3445a8b6f87740ee933c94b4d448fb7d
Quelldatensatz
uspto-grants-2007_05
Patentnummer
US07220769B2

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