Hydrochloric Acid → 2-Ethoxy-4-aminobenzoic acid

HRID 1352657

Reaktionsgleichung

Reaktionsgleichung von HRID 1352657
[CH2:1]([O:3][C:4]1[CH:13]=[C:12]([NH:14]C(=O)C)[CH:11]=[CH:10][C:5]=1[C:6]([O:8]C)=[O:7])[CH3:2].Cl>[OH-].[Na+]>[CH2:1]([O:3][C:4]1[CH:13]=[C:12]([NH2:14])[CH:11]=[CH:10][C:5]=1[C:6]([OH:8])=[O:7])[CH3:2]

Komponenten

4

Edukt 2

HCID 313Hydrochloric AcidHCID 6034Ethopabate

Produkt 1

HCID 101763852-Ethoxy-4-aminobenzoic acidAusbeute 100,2 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 14798Sodium HydroxideLösungsmittel

Versuchsvorschrift

A suspension of methyl 2-ethoxy-4-acetamidobenzoate (50 g, 211 mmol) in aqueous solution of NaOH (15% W/W, 200 ml) was gently refluxed for 16 hours. The resulting pale brown solution was allowed to cool to room temperature and then further cooled in an ice water bath. Concentrated HCl (37% w/w) was added until the solution reached a pH of 6. The solid precipitated from the solution was filtered under vacuum, dried at 50° C. to give 38.3 g of the title compound (yield 100%).

Aufarbeitung

  1. temperaturewas gently refluxed for 16 hours
  2. temperaturefurther cooled in an ice water bath
  3. customThe solid precipitated from the solution
  4. filtrationwas filtered under vacuum
  5. customdried at 50° C.

Quellen und Nachweise

ORD-Eintrag
ord-f89630faf6d341dabf6823615714d1c1
Quelldatensatz
uspto-grants-2007_05
Patentnummer
US07220769B2

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