Hydrochloric Acid → Ethyl 3-amino-3-phenylpropanoate

HRID 1353036

Reaktionsgleichung

Reaktionsgleichung von HRID 1353036
[NH2:1][C@H:2]([CH2:9][C:10]([OH:12])=[O:11])[C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=1.Cl.[CH2:14](O)[CH3:15]>>[NH2:1][CH:2]([C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=1)[CH2:9][C:10]([O:12][CH2:14][CH3:15])=[O:11]

Komponenten

4

Edukt 3

HCID 313Hydrochloric AcidHCID 702EthanolHCID 686703(3R)-3-amino-3-phenylpropanoic acid

Produkt 1

HCID 236379Ethyl 3-amino-3-phenylpropanoate

Versuchsvorschrift

β-Phenylalanine from II.2a (93) was suspended in ethanol (1.5 l) and the solution was saturated with gaseous HCl at room temperature. It was then heated under reflux for 4 h and stirred overnight at room temperature. The solution was cooled to 5° C. and filtered with suction. The filtrate was concentrated in vacuo, and the residue was washed with ether and dried. A white solid was obtained (yield: 52 g).

Aufarbeitung

  1. temperatureIt was then heated
  2. temperatureunder reflux for 4 h
  3. temperatureThe solution was cooled to 5° C.
  4. filtrationfiltered with suction
  5. concentrationThe filtrate was concentrated in vacuo
  6. washthe residue was washed with ether
  7. customdried
  8. customA white solid was obtained (yield: 52 g)

Quellen und Nachweise

ORD-Eintrag
ord-0ca7caf733524f749acffc30ae2cc99b
Quelldatensatz
uspto-grants-2007_05
Patentnummer
US07220824B1

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