Reaktionsgleichung
[CH:1]1[CH:2]=[CH:3][C:4]2[C:5](=[CH:7][N:8]=[N:9][C:10]=2[NH:11][NH2:12])[CH:6]=1.[ClH:13]>>[CH:1]1[CH:2]=[CH:3][C:4]2[C:5](=[CH:7][N:8]=[N:9][C:10]=2[NH:11][NH2:12])[CH:6]=1.[ClH:13]Komponenten
3
Versuchsvorschrift
Hydralazine free base (1 part by weight) was heated in 6 to 7 parts by volume of 15% hydrochloric acid to a temperature of 70–80° C. The solution was filtered hot to remove traces of insoluble materials that were undesired by-products of the preceding step. Ethanol (6 to 7 parts by volume) was added to the filtrate. As the resulting solution cooled to ambient temperature and then further to 3–8° C., an off-white to pale yellow precipitate of the desired product, hydralazine hydrochloride, was obtained. Typical yields were 80–90%.
Aufarbeitung
- filtrationThe solution was filtered hot
- customto remove traces of insoluble materials that
- additionEthanol (6 to 7 parts by volume) was added to the filtrate
Quellen und Nachweise
- ORD-Eintrag
- ord-9170f19dc8204b22a9102a5d846f882b
- Quelldatensatz
- uspto-grants-2007_05
- Patentnummer
- US07220858B2
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