N,N-Dimethylaniline → 2,6-Di(propan-2-yl)phenyl carbonochloridate

HRID 1353175

Reaktionsgleichung

Reaktionsgleichung von HRID 1353175
[C:1]([Cl:4])(Cl)=[O:2].[CH3:5][CH:6]([C:8]1[CH:9]=[CH:10][CH:11]=[C:12]([CH:15]([CH3:17])[CH3:16])[C:13]=1[OH:14])[CH3:7].CN(C)C1C=CC=CC=1>>[CH:15]([C:12]1[CH:11]=[CH:10][CH:9]=[C:8]([CH:6]([CH3:7])[CH3:5])[C:13]=1[O:14][C:1]([Cl:4])=[O:2])([CH3:17])[CH3:16]

Komponenten

4

Edukt 3

HCID 949N,N-DimethylanilineHCID 4943PropofolHCID 6371Phosgene

Produkt 1

HCID 2716192,6-Di(propan-2-yl)phenyl carbonochloridate

Reaktionsbedingungen

Temperatur
0 °C

Versuchsvorschrift

Phosgene (13 mL, 20% in toluene) was added to propofol (3.6 g, 20 mmol) under a nitrogen atmosphere. The mixture was cooled to 0° C. and N,N-dimethylaniline (3.3 mL, 26 mmol) was added dropwise. The reaction mixture was allowed to warm to room temperature slowly and stirred for 14 h. The solvent was removed in vacuo. The crude product was carried to next step without further purification.

Aufarbeitung

  1. temperatureto warm to room temperature slowly
  2. customThe solvent was removed in vacuo
  3. customThe crude product was carried to next step without further purification

Quellen und Nachweise

ORD-Eintrag
ord-3a3bb6e61312458e836096027f049d39
Quelldatensatz
uspto-grants-2007_05
Patentnummer
US07220875B2

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