(2S)-3-[4-(1-tert-butoxycarbonyl-1-methyl-ethoxy)-phenyl]-2-methoxy-propionic acid ethyl ester → (2S)-3-[4-(1-carboxy-1-methyl-ethoxy)-phenyl]-2-methoxy-propionic acid ethyl ester

HRID 1353212Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1353212
[CH2:1]([O:3][C:4](=[O:26])[C@@H:5]([O:24][CH3:25])[CH2:6][C:7]1[CH:12]=[CH:11][C:10]([O:13][C:14]([C:17]([O:19]C(C)(C)C)=[O:18])([CH3:16])[CH3:15])=[CH:9][CH:8]=1)[CH3:2].C(OC(=O)[C@@H](OC)CC1C=CC(OCC(O)=O)=CC=1)C>>[CH2:1]([O:3][C:4](=[O:26])[C@@H:5]([O:24][CH3:25])[CH2:6][C:7]1[CH:12]=[CH:11][C:10]([O:13][C:14]([C:17]([OH:19])=[O:18])([CH3:15])[CH3:16])=[CH:9][CH:8]=1)[CH3:2]

Komponenten

3

Edukt 2

HCID 58646618(2S)-3-[4-(1-tert-butoxycarbonyl-1-methyl-ethoxy)-phenyl]-2-methoxy-propionic acid ethyl esterHCID 58864673(2S)-3-(4-carboxymethoxy-phenyl)-2-methoxy-propionic acid ethyl ester

Produkt 1

HCID 58646603(2S)-3-[4-(1-carboxy-1-methyl-ethoxy)-phenyl]-2-methoxy-propionic acid ethyl ester

Versuchsvorschrift

The title compound was prepared from (2S)-3-[4-(1-tert-butoxycarbonyl-1-methyl-ethoxy)-phenyl]-2-methoxy-propionic acid ethyl ester (PREPARATION 5, step 1) via the same procedure used to prepare (2S)-3-(4-carboxymethoxy-phenyl)-2-methoxy-propionic acid ethyl ester (example 121, step 2) to produce a yellow oil. 1H-NMR (CDCl3, 200.15 MHz): 7.10 (d, 2H, J=8.3), 6.77 (d, 2H, J=8.3), 4.14 (c, 2H, J=6.9), 3.89 (t, 1H, J=6.5), 3.34 (s, 3H), 2.94 (d, 2H, J=6.5), 1.55 (s, 6H), 1.19 (t, 3H, J=6.9).

Aufarbeitung

  1. customto produce a yellow oil

Quellen und Nachweise

ORD-Eintrag
ord-fc36784cfe444e2bb35095fe0188ccb2
Quelldatensatz
uspto-grants-2007_05
Patentnummer
US07220880B2

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