Hydrochloric Acid → (4-Isopropyl-piperazin-1-yl)-(4-morpholin-4-ylmethyl-phenyl)-methanone, dihydrochloride monohydrate

HRID 13540

Reaktionsgleichung

Reaktionsgleichung von HRID 13540
[CH:1]([N:4]1[CH2:9][CH2:8][N:7]([C:10]([C:12]2[CH:17]=[CH:16][C:15]([CH2:18][N:19]3[CH2:24][CH2:23][O:22][CH2:21][CH2:20]3)=[CH:14][CH:13]=2)=[O:11])[CH2:6][CH2:5]1)([CH3:3])[CH3:2].[ClH:25].CC(OC)(C)C>CCO>[OH2:11].[ClH:25].[ClH:25].[CH:1]([N:4]1[CH2:9][CH2:8][N:7]([C:10]([C:12]2[CH:13]=[CH:14][C:15]([CH2:18][N:19]3[CH2:20][CH2:21][O:22][CH2:23][CH2:24]3)=[CH:16][CH:17]=2)=[O:11])[CH2:6][CH2:5]1)([CH3:3])[CH3:2]

Komponenten

5

Edukt 3

HCID 313Hydrochloric AcidHCID 15413tert-Butyl methyl etherHCID 10042344(4-Isopropyl-piperazin-1-yl)-(4-morpholin-4-ylmethyl-phenyl)-methanone

Produkt 1

HCID 131728157(4-Isopropyl-piperazin-1-yl)-(4-morpholin-4-ylmethyl-phenyl)-methanone, dihydrochloride monohydrate

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Reaktionsbedingungen

Temperatur
0 °C

Versuchsvorschrift

A solution of (4-isopropyl-piperazin-1-yl)-(4-morpholin-4-ylmethyl -phenyl)-methanone (2.0 g, 6.0 mmol) in absolute EtOH (20 mL) was treated with HCl(g) (0.5 g, 13.7 mmol) at room temperature. The resulting suspension was stirred for 1 h, and then MTBE (5 mL) was added. The suspension was cooled to 0° C. and filtered. The filter cake was washed with MTBE (20 mL), and the solid was dried in a vacuum oven at 60° C. for 20 h to yield crude title compound as a white solid.

Aufarbeitung

  1. filtrationfiltered
  2. washThe filter cake was washed with MTBE (20 mL)
  3. customthe solid was dried in a vacuum oven at 60° C. for 20 h

Quellen und Nachweise

ORD-Eintrag
ord-b01d08a8a44a47019d8d36b8551d3671
Quelldatensatz
uspto-grants-2010_06
Patentnummer
US07728129B2

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