Ethanol → [2-(6-Methoxy-quinazolin-4-yl)-ethyl]-1,4-dioxa-spiro[4.5]decan-8-ol

HRID 1354206Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1354206
[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:10](=[CH:11][CH:12]=1)[N:9]=[CH:8][N:7]=[C:6]2[C:13]#[C:14][C:15]1([OH:25])[CH2:24]CC2(OCCO2)CC1.[CH3:26][CH2:27][OH:28]>C1COCC1.[Pt]=O>[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:10](=[CH:11][CH:12]=1)[N:9]=[CH:8][N:7]=[C:6]2[CH2:13][CH2:14][CH:15]1[CH2:24][O:28][C:27]2([CH2:11][CH2:12][CH:3]([OH:2])[CH2:4][CH2:26]2)[O:25]1

Komponenten

5

Edukt 2

HCID 702EthanolHCID 211046688-(6-Methoxy-quinazolin-4-ylethynyl)-1,4-dioxa-spiro[4.5]decan-8-ol

Produkt 1

HCID 86603231[2-(6-Methoxy-quinazolin-4-yl)-ethyl]-1,4-dioxa-spiro[4.5]decan-8-ol

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 82844Platinum oxide (PtO)KatalysatorHCID 8028TetrahydrofuranLösungsmittel

Versuchsvorschrift

Platinum oxide (0.46 g) was added to a solution of 8-(6-methoxy-quinazolin-4-ylethynyl)-1,4-dioxa-spiro[4.5]decan-8-ol (0.96 g, 2.88 mmol) in EtOH (40 ml) and THF (10 ml), and hydrogenation was carried out under a hydrogen atmosphere (1 bar). The reaction mixture was stirred in the presence of activated carbon (5 g) and filtered. The filtrate was concentrated to dryness by rotary evaporation. The residue was purified by column chromatography on silica gel (EtOAc and then EtOAc:MeOH 9/1).

Aufarbeitung

  1. filtrationfiltered
  2. concentrationThe filtrate was concentrated to dryness by rotary evaporation
  3. customThe residue was purified by column chromatography on silica gel (EtOAc

Quellen und Nachweise

ORD-Eintrag
ord-5d443ac33af84a09a6b4388cf7724908
Quelldatensatz
uspto-grants-2007_05
Patentnummer
US07223776B2

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