8-[2-(6-Methoxy-[1,5]naphthyridin-4-yl)ethyl]-1,4-dioxa-spiro[4.5]decan-8-ol → 4-Hydroxy-4-[2-(6-methoxy-[1,5]naphthyridin-4-yl)ethyl]-cyclohexanone

HRID 1354213Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1354213
[CH3:1][O:2][C:3]1[N:4]=[C:5]2[C:10](=[CH:11][CH:12]=1)[N:9]=[CH:8][CH:7]=[C:6]2[CH2:13][CH2:14][C:15]1([OH:25])[CH2:24][CH2:23][C:18]2(OCC[O:19]2)[CH2:17][CH2:16]1>C1COCC1.O.CC(O)=O>[OH:25][C:15]1([CH2:14][CH2:13][C:6]2[C:5]3[C:10](=[CH:11][CH:12]=[C:3]([O:2][CH3:1])[N:4]=3)[N:9]=[CH:8][CH:7]=2)[CH2:24][CH2:23][C:18](=[O:19])[CH2:17][CH2:16]1

Komponenten

3

Edukt 1

HCID 211046648-[2-(6-Methoxy-[1,5]naphthyridin-4-yl)ethyl]-1,4-dioxa-spiro[4.5]decan-8-ol

Produkt 1

HCID 211046474-Hydroxy-4-[2-(6-methoxy-[1,5]naphthyridin-4-yl)ethyl]-cyclohexanone

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 21877175AcOH THF waterLösungsmittel

Versuchsvorschrift

A solution of 8-[2-(6-methoxy-[1,5]naphthyridin-4-yl)ethyl]-1,4-dioxa-spiro[4.5]decan-8-ol (960 mg, 2.79 mmol) in THF/H2O/AcOH (2:2:3, 22 ml) was stirred overnight at 65° C. The reaction mixture was concentrated and purified by chromatography on silica gel (EtOAc).

Aufarbeitung

  1. concentrationThe reaction mixture was concentrated
  2. custompurified by chromatography on silica gel (EtOAc)

Quellen und Nachweise

ORD-Eintrag
ord-ef1a6486a5f048c48395fed3cef70c37
Quelldatensatz
uspto-grants-2007_05
Patentnummer
US07223776B2

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