Pyridine → HCID 21105105, Verbindung

HRID 1354271Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1354271
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]2[C:12]([C:13]([F:16])([F:15])[F:14])=[C:11]([C:17](Cl)=[O:18])[CH:10]=[N:9]2)=[CH:4][CH:3]=1.[NH2:20][C:21]1[CH:22]=[C:23]([S:27]([F:30])(=[O:29])=[O:28])[CH:24]=[CH:25][CH:26]=1.N1C=CC=CC=1>C(Cl)Cl>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]2[C:12]([C:13]([F:16])([F:15])[F:14])=[C:11]([C:17]([NH:20][C:21]3[CH:22]=[C:23]([S:27]([F:30])(=[O:29])=[O:28])[CH:24]=[CH:25][CH:26]=3)=[O:18])[CH:10]=[N:9]2)=[CH:4][CH:3]=1

Komponenten

5

Edukt 3

HCID 1049PyridineHCID 677803-Aminobenzene-1-sulfonyl fluorideHCID 27366451-(4-Chlorophenyl)-5-(trifluoromethyl)-1H-pyrazole-4-carbonyl chloride

Produkt 1

HCID 21105105HCID 21105105, VerbindungAusbeute 74,4 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

1-(4-Chloro-phenyl)-5-trifluoromethyl-1H-pyrazole-4-carbonyl chloride (3.00 g, 9.70 mmol) was added to 3-amino-benzenesulfonyl fluoride (1.87 g, 10.6 mmol) in CH2Cl2 (50 ml) containing pyridine (2.35 ml, 29.1 mmol). Reaction mixture stirred overnight at room temperature, concentrated under reduced pressure and crude product purified by column chromatography to give 3-{[1-(4-chloro-phenyl)-5-trifluoromethyl-1H-pyrazole-4-carbonyl]-amino}-benzenesulfonyl fluoride (3.23 g, 74%).

Aufarbeitung

  1. customReaction mixture
  2. concentrationconcentrated under reduced pressure and crude product
  3. custompurified by column chromatography

Quellen und Nachweise

ORD-Eintrag
ord-0a4e76a66c024c95a5f8d7a344581084
Quelldatensatz
uspto-grants-2007_05
Patentnummer
US07223782B2

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