[C:1]([C:3]1[C:7]([CH3:8])=[N:6][N:5]([CH3:9])[C:4]=1[NH:10][C:11](=O)[C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][C:13]=1[F:18])#[N:2].[OH:20]O.Cl>[OH-].[Na+]>[F:18][C:13]1[CH:14]=[CH:15][CH:16]=[CH:17][C:12]=1[C:11]1[NH:2][C:1](=[O:20])[C:3]2[C:7]([CH3:8])=[N:6][N:5]([CH3:9])[C:4]=2[N:10]=1N-(4-Cyano-2,5-dimethyl-2H-pyrazol-3-yl)-2-fluoro-benzamide (5.0 g, 19.36 mmole) was suspended in 38 ml 1M sodium hydroxide and heated to 90° C. for 3 hours followed by addition of 30% hydrogen peroxide (10 ml) and further heating overnight. Cooled reaction mixture to room temperature and acidified with dilute hydrochloric acid. Product was isolated by filtration, washed with water, and dried overnight under vacuum to obtain 3.39 g product. (Yield 67%).
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