Tetrahydrofuran → 6-(4-Biphenylylmethoxy)nicotinic Acid

HRID 1356447Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1356447
[C:1]1([C:19]2[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=2)[CH:6]=[CH:5][C:4]([CH2:7][O:8][C:9]2[CH:18]=[CH:17][C:12]([C:13]([O:15]C)=[O:14])=[CH:11][N:10]=2)=[CH:3][CH:2]=1.C1COCC1>CO.[OH-].[Na+].Cl>[C:1]1([C:19]2[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=2)[CH:6]=[CH:5][C:4]([CH2:7][O:8][C:9]2[CH:18]=[CH:17][C:12]([C:13]([OH:15])=[O:14])=[CH:11][N:10]=2)=[CH:3][CH:2]=1

Komponenten

6

Edukt 2

HCID 8028TetrahydrofuranHCID 18508353Methyl 6-(4-biphenylylmethoxy)nicotinate

Produkt 1

HCID 178174806-(4-Biphenylylmethoxy)nicotinic AcidAusbeute 83,7 %

Reagenzien, Katalysatoren, Lösungsmittel 3

HCID 313Hydrochloric AcidLösungsmittelHCID 887MethanolLösungsmittelHCID 14798Sodium HydroxideLösungsmittel

Versuchsvorschrift

To a solution of methyl 6-(4-biphenylylmethoxy)nicotinate (2.0 g) in methanol (20 ml)/THF(40 ml) was added iN aqueous sodium hydroxide (13 ml) at room temperature. After stirring at room temperature for 4 hr the reaction mixture was diluted with 1 N hydrochloric acid (13 ml) and concentrated. The precipitate was collected by filtration and washed with water and diethyl ether sequentially to obtain the titled compound (1.6 g) as amorphous powder.

Aufarbeitung

  1. concentrationconcentrated
  2. filtrationThe precipitate was collected by filtration
  3. washwashed with water and diethyl ether sequentially

Quellen und Nachweise

ORD-Eintrag
ord-dfbdd527ca69446aba9847ef571372c9
Quelldatensatz
uspto-grants-2003_07
Patentnummer
US06586475B1

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