Potassium Carbonate → N-Boc-N-methylethylenediamine

HRID 1356451Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1356451
[C:1]([O:5][C:6](=[O:18])[N:7]([CH3:17])[CH2:8][CH2:9][NH:10]C(=O)C(F)(F)F)([CH3:4])([CH3:3])[CH3:2].C(=O)([O-])[O-].[K+].[K+]>CO>[NH2:10][CH2:9][CH2:8][N:7]([CH3:17])[C:6](=[O:18])[O:5][C:1]([CH3:2])([CH3:3])[CH3:4]

Komponenten

4

Edukt 2

HCID 11430Potassium CarbonateHCID 10635722Methyl-[2-(2,2,2-trifluoro-acetylamino)-ethyl]-carbamic acid tert-butyl ester

Produkt 1

HCID 2756424N-Boc-N-methylethylenediamineAusbeute 70 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Versuchsvorschrift

To a solution of tert-butyl(methyl)[2-[(2,2,2-trifluoroacetyl)amino]ethyl]carbamate (1 g) in methanol (10 ml) in an ice bath was added aqueous 10% potassium carbonate (5 ml). After addition, the reaction mixture was warmed to room temperature and stirring was continued for additional 20 hr. The reaction mixture was concentrated and the residue was dissolved in ethyl acetate. The insoluble material was removed by filtration and the filtrate was concentrated to obtain the titled compound (451 mg).

Aufarbeitung

  1. additionAfter addition
  2. concentrationThe reaction mixture was concentrated
  3. dissolutionthe residue was dissolved in ethyl acetate
  4. customThe insoluble material was removed by filtration
  5. concentrationthe filtrate was concentrated

Quellen und Nachweise

ORD-Eintrag
ord-bf33dcfdf58a4d7faa9109b1524ea199
Quelldatensatz
uspto-grants-2003_07
Patentnummer
US06586475B1

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