Tert-Butylamine → (s)-3,4-Epoxybutyric acid t-butylamine salt

Beteiligte Stoffe

Reaktionsschritte

To a 2 l of three-necked flask equipped with thermometer, pH meter and mechanical stirrer were charged distilled water (1 l), (S)-3-acetoxy-4-bromobutyric acid (90 g, 0.4 mol) and t-butylamine (88 g, 1.2 mol). The reaction mixture was stirred at 0˜5° C. for 2 hours to afford (S)-3,4-epoxybutyric acid t-butylamine salt. Over 99% of conversion was detected by NMR.

Herkunft & Nachweise