Potassium Carbonate → 3'-[N-(4-tert-Butylbenzyl)-N-cyclopropylaminomethyl]acetophenone

HRID 1356836Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1356836
[CH:1]1([NH:4][CH2:5][C:6]2[CH:7]=[C:8]([C:12](=[O:14])[CH3:13])[CH:9]=[CH:10][CH:11]=2)[CH2:3][CH2:2]1.C(=O)([O-])[O-].[K+].[K+].[C:21]([C:25]1[CH:32]=[CH:31][C:28]([CH2:29]Br)=[CH:27][CH:26]=1)([CH3:24])([CH3:23])[CH3:22]>CN(C)C=O>[C:21]([C:25]1[CH:26]=[CH:27][C:28]([CH2:29][N:4]([CH2:5][C:6]2[CH:7]=[C:8]([C:12](=[O:14])[CH3:13])[CH:9]=[CH:10][CH:11]=2)[CH:1]2[CH2:2][CH2:3]2)=[CH:31][CH:32]=1)([CH3:24])([CH3:22])[CH3:23]

Komponenten

5

Edukt 3

HCID 11430Potassium CarbonateHCID 878361-(Bromomethyl)-4-(1,1-dimethylethyl)benzeneHCID 185094213'-(N-Cyclopropylaminomethyl)acetophenone

Produkt 1

HCID 185095303'-[N-(4-tert-Butylbenzyl)-N-cyclopropylaminomethyl]acetophenoneAusbeute 39,5 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6228DimethylformamideLösungsmittel2×

Versuchsvorschrift

3′-(N-cyclopropylaminomethyl)acetophenone (0.30 g; 1.59 mmol) and potassium carbonate (0.31 g; 2.27 mmol) were added to N,N-dimethylformamide (15 ml). While the mixture was stirred at room temperature, 4-tert-butylbenzyl bromide (0.29 g; 1.51 mmol) in N,N-dimethylformamide (5 ml) was added dropwise. The mixture was stirred for 1 hour at room temperature, and the reaction was stopped by pouring the mixture into ice+saturated aqueous sodium bicarbonate solution, followed by extraction with ethyl acetate (100 ml). The organic layer was washed with saturated aqueous sodium bicarbonate solution and then with saturated brine, and dried over anhydrous sodium sulfate. The solvent was evaporated under reduced pressure, and the residue was purified by silica gel column chromatography (n-hexane:ethyl acetate=15:1), to thereby yield 0.20 g of the target compound as colorless transparent oily matter (yield: 39.5%).

Aufarbeitung

  1. stirringThe mixture was stirred for 1 hour at room temperature
  2. additionby pouring the mixture into ice+saturated aqueous sodium bicarbonate solution
  3. extractionfollowed by extraction with ethyl acetate (100 ml)
  4. washThe organic layer was washed with saturated aqueous sodium bicarbonate solution
  5. dry with materialwith saturated brine, and dried over anhydrous sodium sulfate
  6. customThe solvent was evaporated under reduced pressure
  7. customthe residue was purified by silica gel column chromatography (n-hexane:ethyl acetate=15:1)

Quellen und Nachweise

ORD-Eintrag
ord-939cf9f1eee9476ab5a84ecfcfee6be6
Quelldatensatz
uspto-grants-2003_07
Patentnummer
US06586633B1

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