Methanol → Methyl 1-benzofuran-2-carboxylate

HRID 1357178

Reaktionsgleichung

Reaktionsgleichung von HRID 1357178
S(Cl)(Cl)=O.[O:5]1[C:9]2[CH:10]=[CH:11][CH:12]=[CH:13][C:8]=2[CH:7]=[C:6]1[C:14]([OH:16])=[O:15].[CH3:17]O>>[O:5]1[C:9]2[CH:10]=[CH:11][CH:12]=[CH:13][C:8]=2[CH:7]=[C:6]1[C:14]([O:16][CH3:17])=[O:15]

Komponenten

4

Edukt 3

HCID 887MethanolHCID 10331Benzofuran-2-carboxylic acidHCID 24386Thionyl Chloride

Produkt 1

HCID 291153Methyl 1-benzofuran-2-carboxylate

Versuchsvorschrift

After adding thionyl chloride (3.80 ml) to a solution of 2-benzofurancarboxylic acid (2.00 g) in MeOH (60 ml) at −40° C., the mixture was stirred for 19 hours while the temperature gradually increased to room temperature. The reaction solution was concentrated under reduced pressure and the residue was purified by silica gel column chromatography (n-hexane/AcOEt=6/1) to obtain methyl 2-benzofurancarboxylate.

Aufarbeitung

  1. concentrationThe reaction solution was concentrated under reduced pressure
  2. customthe residue was purified by silica gel column chromatography (n-hexane/AcOEt=6/1)

Quellen und Nachweise

ORD-Eintrag
ord-5f4526a0eb564e81b5579c84793da54b
Quelldatensatz
uspto-grants-2003_07
Patentnummer
US06589984B1

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