2-Fluoro-5-(hydroxymethyl)benzonitrile → 2-Fluoro-5-formylbenzonitrile

HRID 1357737Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1357737
[C:1]([C:3]1[CH:4]=[C:5]([CH:8]=[CH:9][C:10]=1[F:11])[CH2:6][OH:7])#[N:2]>C(Cl)(Cl)Cl.[O-2].[O-2].[Mn+4]>[C:1]([C:3]1[CH:4]=[C:5]([CH:8]=[CH:9][C:10]=1[F:11])[CH:6]=[O:7])#[N:2]

Komponenten

4

Edukt 1

HCID 27739342-Fluoro-5-(hydroxymethyl)benzonitrile

Produkt 1

HCID 27695822-Fluoro-5-formylbenzonitrileAusbeute 54,2 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 178418406HCID 178418406, VerbindungKatalysatorHCID 6212ChloroformLösungsmittel

Versuchsvorschrift

A solution of the product from Example 82B (0.40 g, 2.6 mmol) in chloroform (50 mL) was treated with manganese dioxide (0.55 g, 7.8 mmol), stirred at room temperature overnight, filtered, solvent evaporated and the residue flash chromatographed over silica gel eluting with ethyl acetate:hexane (1:1) to provide 0.21 g 3-cyano-4-fluorobenzaldehyde.

Aufarbeitung

  1. filtrationfiltered
  2. customsolvent evaporated
  3. customthe residue flash chromatographed over silica gel eluting with ethyl acetate:hexane (1:1)

Quellen und Nachweise

ORD-Eintrag
ord-e8da21326aaa4db88a74696d6cf7cadc
Quelldatensatz
uspto-grants-2003_07
Patentnummer
US06593335B1

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