HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
Calcium Carbonate → 2,1,3-Benzothiadiazol-5-ylmethanol
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | Calcium Carbonate | HCID 10112 | — |
| Edukt | 5-(Bromomethyl)-2,1,3-benzothiadiazole | HCID 591004 | — |
| Lösungsmittel | 1,4-Dioxane--water (1/1) | HCID 21886435 | — |
| Produkt | 2,1,3-Benzothiadiazol-5-ylmethanol | HCID 2776294 | 76,4% |
Reaktionsschritte
5-Bromomethylbenzo-2,1,3-thiadiazole (4.8 g) and calcium carbonate (10 g) were heated at reflux in 1:1 dioxane/water (120 mL) for 3 hours. The solvents were evaporated and the residue was partitioned between 2N hydrochloric acid and methylene 6 3 chloride. The organic layers were dried (magnesium sulfate), evaporated and chromatographed on silica gel eluting with 1:1 ethyl acetate/hexane to provide 2.66 g of the title compound.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US06593335B1 |
| Quelldatensatz | uspto-grants-2003_07 |
| ORD ID | ord-029bc9b646b04e428b99707522c2021c |
| Quellennotiz | uspto-grants-2003_07 |