Hydrochloric Acid → HCID 131723149, Verbindung

HRID 1357953Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1357953
C(OC([N:8]1[CH2:13][CH2:12][CH:11]([C:14]2[N:18]([CH2:19][CH3:20])[N:17]=[C:16]([CH2:21][CH3:22])[C:15]=2[CH3:23])[CH2:10][CH2:9]1)=O)(C)(C)C.[ClH:24]>CO>[ClH:24].[ClH:24].[CH2:19]([N:18]1[C:14]([CH:11]2[CH2:12][CH2:13][NH:8][CH2:9][CH2:10]2)=[C:15]([CH3:23])[C:16]([CH2:21][CH3:22])=[N:17]1)[CH3:20]

Komponenten

4

Edukt 2

HCID 313Hydrochloric AcidHCID 21912727HCID 21912727, Verbindung

Produkt 1

HCID 131723149HCID 131723149, VerbindungAusbeute 92 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Versuchsvorschrift

A solution of 1-(t-butoxycarbonyl)-4-(1,3-diethyl-4-methyl-(1H)-pyrazol-5-yl)piperidine (348 mg) (from Step E) in 2.5 N HCl in methanol was stirred at rt for 16 h. The solution was concentrated and the resulting solid was suspended in ethyl acetate, filtered and dried to afford 293 mg (92%) of the title compound.

Aufarbeitung

  1. concentrationThe solution was concentrated
  2. filtrationfiltered
  3. customdried

Quellen und Nachweise

ORD-Eintrag
ord-59e19765ea0c45c0805cffacbbc01c4c
Quelldatensatz
uspto-grants-2003_07
Patentnummer
US06593346B2

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