Phosphorus oxychloride → HCID 18184384, Verbindung

HRID 1358264Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1358264
O=[C:2]1[C:11]2[N:10]=[CH:9][N:8]=[CH:7][C:6]=2[CH:5]=[C:4]2[O:12][CH2:13][NH:14][CH:3]12.O=P(Cl)(Cl)[Cl:17]>>[Cl:17][C:2]1[C:11]2[N:10]=[CH:9][N:8]=[CH:7][C:6]=2[CH:5]=[C:4]2[O:12][CH:13]=[N:14][C:3]=12

Komponenten

3

Edukt 2

HCID 24813Phosphorus oxychlorideHCID 69704031HCID 69704031, Verbindung

Produkt 1

HCID 18184384HCID 18184384, VerbindungAusbeute 22 %

Versuchsvorschrift

A suspension of 4-oxo-3H-oxazolo[5,4-g]quinazoline (0.98 g, 5.24 mmol) in POCl3 (30 mL) is heated under reflux with vigorous stirring for 18 h, and then concentrated to dryness. The residue is partitioned between EtOAc and saturated aqueous NaHCO3 and the organic portion is worked up to give 4-chlorooxazolo[5,4-g]quinazoline (0.24 g, 22%) as a yellow solid which is used directly.

Aufarbeitung

  1. temperatureis heated
  2. temperatureunder reflux
  3. concentrationconcentrated to dryness
  4. customThe residue is partitioned between EtOAc and saturated aqueous NaHCO3

Quellen und Nachweise

ORD-Eintrag
ord-0d4db61eb5d440e8a3773f8ba3cafc8a
Quelldatensatz
uspto-grants-2003_07
Patentnummer
US06596726B1

Notizen zur Reaktion

Wird geladen…