4,6-Dichloro-5-(o-methoxyphenoxy)-2-methyl-pyrimidine → 5-methyl-N-[6-chloro-5-(o-methoxyphenoxy)-2-methyl-4-pyrimidinyl]-2-pyridine sulfonamide

HRID 1358354

Reaktionsgleichung

Reaktionsgleichung von HRID 1358354
[CH3:1][O:2][C:3]1[CH:18]=[CH:17][CH:16]=[CH:15][C:4]=1[O:5][C:6]1[C:7]([Cl:14])=[N:8][C:9]([CH3:13])=[N:10][C:11]=1Cl.[K+].[CH3:20][C:21]1[CH:22]=[CH:23][C:24]([S:27]([NH-:30])(=[O:29])=[O:28])=[N:25][CH:26]=1>>[CH3:20][C:21]1[CH:22]=[CH:23][C:24]([S:27]([NH:30][C:11]2[C:6]([O:5][C:4]3[CH:15]=[CH:16][CH:17]=[CH:18][C:3]=3[O:2][CH3:1])=[C:7]([Cl:14])[N:8]=[C:9]([CH3:13])[N:10]=2)(=[O:29])=[O:28])=[N:25][CH:26]=1

Komponenten

3

Edukt 2

HCID 219795994,6-Dichloro-5-(o-methoxyphenoxy)-2-methyl-pyrimidineHCID 1317239925-Methyl-2-pyridine sulfonamide potassium salt

Produkt 1

HCID 227293975-methyl-N-[6-chloro-5-(o-methoxyphenoxy)-2-methyl-4-pyrimidinyl]-2-pyridine sulfonamide

Versuchsvorschrift

According to the procedure described in Example 1g) 1.00 g 5-(o-methoxyphenoxy)-4,6-dichloro-2-methyl-pyrimidine was reacted with 5-methyl-2-pyridine sulfonamide potassium salt to give 1.5 g 5-methyl-N-[6-chloro-5-(o-methoxyphenoxy)-2-methyl-4-pyrimidinyl]-2-pyridine sulfonamide. LC-MS: tR=4.57 min, [M+1]+=421.42, [M−1]−=419.46.

Quellen und Nachweise

ORD-Eintrag
ord-4e37578a277845f9afcfb41163e55b40
Quelldatensatz
uspto-grants-2003_07
Patentnummer
US06596719B1

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