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N-bromobutanimide → 6'-Methyl-2'-bromomethyl-2-(4-methoxybenzoyl)-biphenyl-4-carbonitrile

HRID 1359151
Notizen
Druckvorschau

Reaktionsgleichung

Reaktionsgleichung von HRID 1359151
CO[C:3]1[CH:8]=[C:7]([CH3:9])[C:6]([C:10]2[CH:15]=[CH:14][C:13]([C:16]#[N:17])=[CH:12][C:11]=2[C:18](=[O:27])[C:19]2[CH:24]=[CH:23][C:22]([O:25][CH3:26])=[CH:21][CH:20]=2)=[C:5]([CH3:28])[CH:4]=1.C1C(=O)N([Br:36])C(=O)C1.C1C(=O)N(Br)C(=O)C1.CC(N=NC(C#N)(C)C)(C#N)C>C(Cl)(Cl)(Cl)Cl.CC(N=NC(C#N)(C)C)(C#N)C>[CH3:28][C:5]1[C:6]([C:10]2[CH:15]=[CH:14][C:13]([C:16]#[N:17])=[CH:12][C:11]=2[C:18](=[O:27])[C:19]2[CH:24]=[CH:23][C:22]([O:25][CH3:26])=[CH:21][CH:20]=2)=[C:7]([CH2:9][Br:36])[CH:8]=[CH:3][CH:4]=1
KomponentenVersuchsvorschriftAufarbeitungQuellen und NachweiseNotizen zur Reaktion

Komponenten

6

Edukt 3

HCID 67184N-bromobutanimideHCID 108940114'-Methoxy-2',6'-dimethyl-2-(4-methoxybenzoyl)-biphenyl-4-carbonitrileHCID 86630000Nbs aibn

Produkt 1

HCID 181827486'-Methyl-2'-bromomethyl-2-(4-methoxybenzoyl)-biphenyl-4-carbonitrileAusbeute 93,6 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 6547
Azobisisobutyronitrile
Katalysator
2×
HCID 5943Carbon TetrachlorideLösungsmittel

Versuchsvorschrift

To a refluxing solution of the compound from Step D (45.5 g, 122 mmol) and AIBN (1.0 g) in CCl4 (2.5 L) was added a mixture of NBS (23.0 g, 129 mmol) and AIBN (1.0 g) in ten equal portions. The reaction mixture was refluxed for 2 h after the addition of the last portion of NBS/AIBN. The reaction mixture was concentrated to approximately 1 L and washed 3 times with water (1 L). The organic layer was dried with anhydrous Na2SO4, filtered and the solvent removed. Toluene (200 ml) was added to the residue and then evaporated. Repeating this procedure gave 48 g of the title compound that was used without further purification.

Aufarbeitung

  1. temperatureThe reaction mixture was refluxed for 2 h
  2. concentrationThe reaction mixture was concentrated to approximately 1 L
  3. washwashed 3 times with water (1 L)
  4. dry with materialThe organic layer was dried with anhydrous Na2SO4
  5. filtrationfiltered
  6. customthe solvent removed
  7. additionToluene (200 ml) was added to the residue
  8. customevaporated

Quellen und Nachweise

ORD-Eintrag
ord-3ec49c2663994f3995567c06e06a9d32
Quelldatensatz
uspto-grants-2003_07
DOI
10.6084/m9.figshare.5104873.v1
Patentnummer
US06599921B2

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