Acetone → 1-Methoxy-3-phenylpropan-2-one

HRID 1359416Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1359416
CC(C)=O.[CH3:5][O:6][CH2:7][CH:8]([OH:16])[CH2:9][C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1>CC(O)C>[CH3:5][O:6][CH2:7][C:8]([CH2:9][C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1)=[O:16]

Komponenten

4

Edukt 2

HCID 180AcetoneHCID 135125601-Methoxy-3-phenyl-2-propanol

Produkt 1

HCID 117449711-Methoxy-3-phenylpropan-2-oneAusbeute 73,4 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 3776IsopropanolLösungsmittel

Versuchsvorschrift

20.4 ml of a Jone's reagent was slowly added dropwise into 200 ml of an acetone solution containing 5.1 g of 1-methoxy-3-phenyl-2-propanol. After stirring for 30 minutes at room temperature, 30 ml of 2-propanol was slowly added to the reaction solution. After removing the solvent, water was added thereto and the mixture was extracted with ethyl acetate. The organic phase was washed with brine and the solvent was removed. The residue was subjected to silica gel column chromatography and elute with hexane/ethyl acetate (6:1), to give 3.7 g of the target compound.

Aufarbeitung

  1. customAfter removing the solvent, water
  2. additionwas added
  3. extractionthe mixture was extracted with ethyl acetate
  4. washThe organic phase was washed with brine
  5. customthe solvent was removed
  6. washelute with hexane/ethyl acetate (6:1)

Quellen und Nachweise

ORD-Eintrag
ord-476b05a3d40b4c35bc563713a6029d38
Quelldatensatz
uspto-grants-2003_07
Patentnummer
US06599917B1

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