Hydroquinone → N-(2-Fluorophenyl)-2-(4-hydroxyphenoxy)-N-methylpropanamide

HRID 1359513Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1359513
[F:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[N:8]([CH3:14])[C:9](=[O:13])[CH:10](Br)[CH3:11].[C:15]1([CH:22]=[CH:21][C:19]([OH:20])=[CH:18][CH:17]=1)[OH:16].C(=O)([O-])[O-].[K+].[K+]>[Br-].C([N+](CCCC)(CCCC)CCCC)CCC.C(#N)C>[F:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[N:8]([CH3:14])[C:9](=[O:13])[CH:10]([O:16][C:15]1[CH:22]=[CH:21][C:19]([OH:20])=[CH:18][CH:17]=1)[CH3:11]

Komponenten

6

Edukt 3

HCID 785HydroquinoneHCID 11430Potassium CarbonateHCID 18183268HCID 18183268, Verbindung

Produkt 1

HCID 18183267N-(2-Fluorophenyl)-2-(4-hydroxyphenoxy)-N-methylpropanamideAusbeute 86,4 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 74236Tetrabutylammonium BromideKatalysatorHCID 6342AcetonitrileLösungsmittel

Versuchsvorschrift

N-(2-fluorophenyl)-N-methyl-2-bromo-propionamide(18.2 g, 0.07 mol), hydroquinone(7 g, 0.064 mol), potassium carbonate(10.54 g, 0.076 mol) and tetra-n-butylammonium bromide(1 g) were dissolved in 350 ml of acetonitrile and heated at reflux for 6 hours. The reaction mixture was cooled to room temperature and solid remained during the reaction was filtered out. The filtrate was concentrated under reduced pressure and the crude product was purified by column chromatography(eluent: ethyl acetate/n-hexane=½) to afford 16 g of the target product.

Aufarbeitung

  1. temperatureheated
  2. temperatureat reflux for 6 hours
  3. filtrationwas filtered out
  4. concentrationThe filtrate was concentrated under reduced pressure
  5. customthe crude product was purified by column chromatography(eluent

Quellen und Nachweise

ORD-Eintrag
ord-9c6bfd98356b4e1ea0af081821b69f17
Quelldatensatz
uspto-grants-2003_07
Patentnummer
US06600048B2

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